Validating Techniques for Measurement of Cutaneous Neurofibromas

Objective To assess the reliability and variability of digital calipers, 3D photography, high-frequency ultrasound (HFUS) for measurement cutaneous neurofibromas (cNF) in patients with neurofibromatosis type 1 (NF1). Background cNF affect virtually all NF1 are a major source morbidity. Reliable techniques measuring needed to develop therapies these tumors. Methods Adults were recruited. For each participant, 6 assessed independently by 3 different examiners at 5 time points using HFUS. The intraclass correlation coefficient (ICC) was used intrarater interrater linear volumetric measurements technique, ICC values >0.90 defined as excellent reliability. variation (CV) estimate minimal detectable difference (MDD) technique. Results Fifty-seven across 10 participants evaluated. image acquisition >0.97 within HFUS photography. calipers 0.62–0.88. CV varied tool, vs measurement, tumor size. Conclusions photography demonstrate whereas have good cNF. MDD technique create tables proposed thresholds investigators use guides clinical trials focused on These criteria should be updated performance end is